High plasma uric acid concentration: causes and consequences
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چکیده
منابع مشابه
High plasma uric acid concentration: causes and consequences
High plasma uric acid (UA) is a precipitating factor for gout and renal calculi as well as a strong risk factor for Metabolic Syndrome and cardiovascular disease. The main causes for higher plasma UA are either lower excretion, higher synthesis or both. Higher waist circumference and the BMI are associated with higher insulin resistance and leptin production, and both reduce uric acid excretion...
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In view of the possibility that the uric acid of the blood might be partly "bound" to protein and partly "free" (Benedict and Behre, 1931) and that this might provide some explanation for the phases of gout, it was decided to investigate various methods of ultrafiltration of the plasma uric acid in gouty and normal individuals. Lambie (1940) reported a case of leukaemia with subsequent developm...
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We describe an ultramicromethod for determination of uric acid by a manual procedure. Hydrogen peroxide, formed when uric acid is oxidized in the presence of uricase, oxidatively couples two molecules of p-hydroxyphenylacetic acid in the presence of peroxidase to produce a highly fluorescent compound. The specificity of the uricase reaction is retained, and the fluorometry results in a higher s...
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ژورنال
عنوان ژورنال: Diabetology & Metabolic Syndrome
سال: 2012
ISSN: 1758-5996
DOI: 10.1186/1758-5996-4-12